(A,B) Kaplan–Meier curves for overall survival based on the immunoscore in the validation cohort and entire cohort. (C–E) Kaplan–Meier curves for disease-free survival based on the immunoscore in the training cohort validation cohort, and entire cohort. (F) Joint effects of overall survival stratified by the immunoscore and CRC clinical parameters (stage). (G) Joint effects of overall survival stratified by the immunoscore and CRC clinical parameters (lymph node involvement). (H) A significant difference was observed between the blue and red curves in all four profiles (P<0.05). The different immunescore between the recurrence group and the non-recurrence group (P<0.05).