(A) Schematic summarising interactions and participants in the global RNA-independent mRNA export machinery. Nascent mRNA complexes with THO/TREX and after displacement of UAP56, export factor Nxf1 is recruited. mRNP is delivered to TREX-2 which facilitates the entry to the NPC. Nxf1 interacts with FG-repeats along the NPC and components at the cytoplasmic face catalyse the release of mRNA. (B) TREX and TREX-2 complexes, export factors, nuclear basket and cytoplasmic NPC components across taxa are summarised. Compared components are shown on the left, depicted with small coloured circles. All the experimental characterised components are written. With a dash, components are certainly absent, dotted circles, components identified in silico, but not experimentally characterised yet. Components marked with a double black star have been identified, but participation in mRNA export has not been proven. n.i. component not identified yet.