Figure 2.
Comparisons of nucleoporins across species in selected taxa.
Data collated for H. Sapiens [8], S. cerevisiae [10], S. pombe [12], C. thermophilum [14], C. reinhardtii [17], A. thaliana [18], M. domestica [19], T. thermophila [20], T. brucei [21] species and Chlorarachniophytes and Cryptophyceae species clades [125]. Nucleoporins are listed according to their complex and ring disposition in NPC compartments: the inner ring (IR), outer cytoplasmic and nucleoplasmic rings (CR and NR), membrane ring (Mem. Ring, MR), cytoplasmic filaments (Cyt. Filaments, CF) and nuclear basket (Nuc. Basket, NB). Nucleoporins are additionally coloured by type: FG-nups and linker FG-nups in IR, CR and NR, CF and NB in swamp green; Nup93/Nic96 complex core in IR in blue; core IR scaffold Nups in purple (also present in ORs as connector Nups); OR Nups in orange; pore membrane proteins (POMs) in MR in beige; Cytoplasmic Export platform scaffold in CF in pink; mRNP Remodelling in CF in burgundy, and basket scaffold Nups in NB in light blue. Each row represents an orthologous nucleoporin group. Nucleoporins absent in an organism are indicated by a dash (-). In cases of paralogous duplication within an organism — multiple nucleoporins are listed in square brackets, i.e. [ScNup167 ScNup170]. Alternative nucleoporin names are listed in round brackets, i.e. HsNup42 (HshCG1). Ring stoichiometry noted for IR and ORs. Exclusive Y-complex component distribution in S. pombe is additionally indicated by colour: red for CR-specific and blue for NR-specific. Macronuclei/micronuclei- (MAC-/MIC-) specificity for nucleoporins in Tetrahymena is denoted by Mac- or Mic-prefixes in gene names or * and ** for POMs. Trypanosoma-specific Multi-Complex FG-Nup and Nup76 complexes are shown by additional brackets. In ‘architecture’ column (left) given are the schematic protein fold architectures common for the orthologous Nup groups. Additional unique architectures are indicated for TbNup65 that sports a trans-membrane helix uniquely in its orthologous group (demonstrated on the right), and for lineage-specific Nups TtPOM82, TtNup185, TbNup64, TbNup75, TbNup98, TbNup140 and TbNup149.