Solubilisation of artefenomel (OZ439) during digestion of OZ439 mesylate/ferroquine formulations in milk (left) and residual crystalline OZ439 after digestion of the same drug combination in three different infant formulas (right).
The left panel also illustrates the transformation between the two free base forms of artefenomel during digestion. The dependence of solubilisation on fat content in the different infant formulas is also illustrated on the right, note that lower bar height indicates greater drug solubilisation. Adapted from [72,73] with permission, future requests for reproduction should be made to ACS publications (https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b01333 & https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.0c00475).