Figure 4.
![The bottom right panel illustrates the different diffraction patterns for the mesylate salt, the poorly soluble hydrochloride salt and the free base forms (FB form 1 and FB form 2) of artefenomel. The bottom left panel illustrates the slow transformation over 10 min from the free base form 1 (FB 1) to free base form 2 (FB 2) polymorph in digesting milk measured using in situ synchrotron X-ray scattering. Adapted from [67] with permission, future requests for reproduction should be made to ACS publications (https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00541).](https://port.silverchair-cdn.com/port/content_public/journal/biochemsoctrans/49/4/10.1042_bst20210168/1/bst-2021-0168c.04.png?Expires=1716564856&Signature=BFJh8b9E2NNEOFNX4~fMdFS6-QYrjcOElqbR10Rf0-RO91edK3zf2fSJ3yzF-xHx2NbOqFgrLtsFVPwFLWU-VUKMchkqO~sqsfPPR314zQIE-iW0ZMmcjA1aut-i2pNEvb18NY4L8cgheYnFlYGuHrIjMl2rv5ld-Z9hb1tNxhTNqmpuLHcGzWN1z~nirh1J1RzWvXwWL-HfVVB5ynqN8tsHujPtghxdKxjfyLqEFxha6XmoIfWr0Rz3SGiBQkk6g0W6wL2~An23oCmTMq3lZOWBNu-SljdJJY1cAa3kI-fJwNDdQDhhetjWVtwI8RViTSVHLQpGeKJomwS9MTkghQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Complex salt and polymorphic transformations of artefenomel (OZ439 mesylate) on exposure to biorelevant media and during digestion in milk.
The bottom right panel illustrates the different diffraction patterns for the mesylate salt, the poorly soluble hydrochloride salt and the free base forms (FB form 1 and FB form 2) of artefenomel. The bottom left panel illustrates the slow transformation over 10 min from the free base form 1 (FB 1) to free base form 2 (FB 2) polymorph in digesting milk measured using in situ synchrotron X-ray scattering. Adapted from [67] with permission, future requests for reproduction should be made to ACS publications (https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00541).