Cell migration requires the coordination of various plasma membrane components that link extracellular matrix to the cell cytoskeleton. (A) YAP/TAZ influence the dynamics of the actin cytoskeleton through the expression of Rho GTPase-activating proteins (ARHGAP18, ARHGAP29) and Rho guanine exchange factor (ARHGEF17), which in turn modulates RhoA activity. (B) LAT1/CD98 is a disulfide-linked heterodimer composed of SLC3A2 and SLC7A5 that promotes cell migration and survival by coupling nutrient availability and integrin activity. LAT1/CD98 exports glutamine in exchange of importing amino acids, such as leucine, isoleucine and arginine. SLC3A2 of the LAT1/CD98 heterodimer binds integrins and amplifies integrin-mediated signalling. (C) At the leading edge of the cell, activation of integrin receptors through binding of extracellular matrix (ECM) components promotes focal adhesion complex assembly and the contractile forces generated by the actin cytoskeleton enables movement of the cell. (D) Plasma membrane subdomain caveolae expression is regulated by YAP/TAZ and plays a mechanoprotective role by flattening in response to mechanical forces, such as cellular stretching and osmotic swelling. In migrating cells, caveolae frequently localise to the rear due to low membrane tension. (E) YAP/TAZ-TEAD-mediated transcriptional activity promotes the production of matricellular proteins, such as CYR61 and CTGF. These signalling factors promote cell adhesion, migration and proliferation.