(A) Upstream Hippo pathway serine/threonine kinases control activation of LATS1/2 kinases, which in turn directly phosphorylate YAP/TAZ on multiple serine residues and thereby controls YAP/TAZ transcriptional activity though regulating their subcellular localisation. (B) In the nucleus, YAP/TAZ form transcription complexes with various transcription factors to induce expression of cell cycle regulating genes. The cell cycle is further modulated by YAP/TAZ through its interaction with chromatin-modifying proteins, such as nucleosome remodelling and deacetylase (NuRD) complex and histone methyltransferase (HMT) complex, which promote remodelling of chromatin configuration to control gene transcription programmes. (C) LATS1/2 kinases modulate cell cycle exit during late anaphase or telophase through phosphorylation of CDC26 and CTCF. (D) Cyclin-dependent kinases provide an additional level of regulation of mitosis through direct phosphorylation of YAP and TAZ.