Figure 3.
PARP7 and PARP13 promote the degradation of viral RNA, and PARPs 7, 10, 12 and 13 restrict protein translation. PARPs 12, 13 and 14 localize to stress granules containing stalled translation complexes, and PARP12 promotes vesicle trafficking. PARP9/DTX3L, PARP10 and PARP12 can directly ADP-ribosylate and inhibit viral proteins.
Schematic representation of the antiviral effector functions of PARPs.

PARP7 and PARP13 promote the degradation of viral RNA, and PARPs 7, 10, 12 and 13 restrict protein translation. PARPs 12, 13 and 14 localize to stress granules containing stalled translation complexes, and PARP12 promotes vesicle trafficking. PARP9/DTX3L, PARP10 and PARP12 can directly ADP-ribosylate and inhibit viral proteins.

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