A de novo model of tau cysteine-containing microtubule-binding area (275–325)
(A) A cartoon representation of the tau de novo model (shown with 180° rotation) obtained using QUARK. The tau sequence, corresponding to the second and third MTBDs, is shown using the same colour scheme. (B,C) A 3D cartoon representation (B) and helical wheel diagram (C) of the Cys291 containing α-helix with a theoretical visualisation at the membrane interface. Leu284, Val287 and Cys291 are localised on the same side of the helix. (D,E) A 3D cartoon representation (D) and helical wheel diagram (E) of the Cys322 containing α-helix with a theoretical visualisation at the membrane interface. Leu315, Val318 and Cys322 are localised on the same side of the helix.