Differential expression and GO:BP of genes associated only with Akirin2 in response to akirin2 KO in human HL60 cells
(A) Heatmap of GO:BP annotations and number of genes with KO/WT −2 < log2foldchange > 2 on each BP. Black arrows indicate the BPs associated only with Akirin2. (B) Heatmap of RNAseq results for genes with KO/WT −2 < log2foldchange > 2 and associated only with Akirin2 (Supplementary Data S5). KO4 and WT4 correspond to KO1–KO3 and WT1–WT3 mean values, respectively. Red and blue arrows indicate genes associated with all four BPs or taxis alone, respectively. (C) Gene representation (n, %) in the four BPs, taxis (TA), cell motility (CM), localization of cell (LC) and regulation of cell adhesion (RCA) associated only with Akirin2. Heatmaps were prepared with average linkage and Euclidean distance measurement method.