Cartoon of a HADDOCK model generated using NMR chemical shift titration mapping. The P7 peptide inhibitor is localized to an orthosteric binding site of Cdc42 involving key interactions of the peptide with Cdc42 residues Thr25, Asn26, Val44 and Lys166. The peptide inhibitor P7 is shown in dark blue with Cdc42 in grey (PDB 6R28).