(A) Inflammatory caspases are composed of a CARD domain and a catalytic subunit, divided into a large and a small subunit. Caspases use a catalytic cysteine (shown as a star) to support their catalytic activity. Scissors represent inhibitory (red) and activating (green) self-processing sites. (B) Crystal structure of caspase-1 bound to the active-site inhibitor VX765 (PDB: 6PZP). The large subunit (pink) and the small subunit (cyan) of a caspase-1 dimer interacting with the active site inhibitor VX-765 (orange).