(A) PP1c-sensitive sites are enriched for the often-found RxxpSP motif in IDRs. (B) The trend observed for PP1c in Figure 2A is not the case for ordered regions. In this scenario, the amino acid in −1 seems to be of higher importance compared with −3. (C) PP2Ac has a strong preference for acidic amino acids in disordered protein regions but disfavors basic residues R and K. (D) The trend observed for IDRs and PP2Ac in Figure 2C is not found in ordered regions. As for PP1c, the biggest effects are observed for the amino acid residues closest to the p-site.