Figure 3.
Landscape of SARS-CoV-2 RNA structures as revealed by high-throughput studies.
On the top, the structures of conserved secondary structure elements, supported by significant covariation, as determined by SHAPE analyses of the SARS-CoV-2 genome, with superimposed reactivities from Manfredonia et al. [39] (1, 2, 6, 7, 9, 10, 17) and Huston et al. [36] (3, 4, 5). In addition, the structures of seven stem–loops (8, 11, 12, 13, 14, 15, 16) proposed to enclose the TRS-Bs (boxed in green), with superimposed reactivities from Lan et al. [37], are shown. On the bottom, an arc plot shows the long-range interactions identified by direct RNA–RNA interaction mapping in the SARS-CoV-2 genome, colored according to their relative abundance from Ziv et al. [38]. The FSE-arch is also indicated.