HMGB1 regulates ferroptosis-induced oxidative stress upon exposure to high glucose
Levels of ROS (A) and MDA (B) in DN patients and healthy controls. SV40 MES 13 cells were transfected with HMGB1 siRNA and stimulated with high glucose. The production of ROS (C), IL-6 (E) and TNF-α (F) was detected. Furthermore, SV40 MES 13 cells were treated with eratin and DFX alone or combined with high glucose, and the levels of ROS were detected (D). *P<0.05, **P<0.01, ***P<0.001, compared with control. ##P<0.01, compared with HG group.