The cell proportions of lymphocyte subset of COVID-19 female cases, classified into two age groups: under (38 years, 31–44) (n=9) and over 50 (68 years, 60–76) (n=14) (P<0.0001) years old, which is the average age of women’s menopause with much lower level of estrogen. Non-significant differences in CD4⁺ T, CD8⁺ T and the ratio of CD4⁺/CD8⁺, which was the characteristics of infection by SARS-CoV-2 and associated with the disease severity, between the two groups demonstrated that the differentiations of immune response may be independent of the level of estrogen. Comparisons were done by the Mann–Whitney U test.