The secondary structural model of a L/D-hammerhead ribozyme (Rz) complexed with an L/D-RNA substrate containing GUC↓N, the predetermined cleavage site for hammerhead ribozymes
The arrow identifies specific cleavage site for all ribozymes. Each heterochiral catalytic complex contains the classical Watson–Crick homochiral base pairs forming stem core of ribozyme helix 2, (stem 2), which induce and stabilize heterochiral Watson–Crick like base pairs with substrate helices 1 and 3.