(A) KEGG enrichment analysis showed that pathways associated with ubiquitin mediated proteolysis were significantly enriched in the high-risk group (NES = 2.07; NOM P-val = 0.000; FDR q-val = 0.017; FWER P-val = 0.019). (B) GO enrichment analysis showed that signal sequence binding was significantly enriched in the high-risk group (NES = 2.19; NOM P-val = 0.002; FDR q-val = 0.047; FWER P-val = 0.044); GSEA, Gene Set Enrichment Analysis; KEGG, Kyoto Encyclopedia of Genes and Genomes; GO, Gene Ontology; NES, normalized enrichment score; NOM P-val, adjusted P value by Benjamini; FDR q-val: adjusted q value by false discovery rate; FWER P-val: adjusted P value by Bonferonni.