Figure 6
About 500 nM cognate DNA was incubated with increasing concentrations (5−40 μM) of: (A) FOXP2 LZ-END, (B) FOXP1 LZ-END, (C) FOXP2 LZ-FHD, (D) FOXP2 FHD, (E) FOXP2 FHD-END. All constructs showed DNA binding capability, suggesting that the FHD (DNA-binding domain) is correctly folded and accessible to DNA in all cases.
Protein−DNA complex formation of the FOXP variants as determined by electrophoretic mobility shift assay

About 500 nM cognate DNA was incubated with increasing concentrations (5−40 μM) of: (A) FOXP2 LZ-END, (B) FOXP1 LZ-END, (C) FOXP2 LZ-FHD, (D) FOXP2 FHD, (E) FOXP2 FHD-END. All constructs showed DNA binding capability, suggesting that the FHD (DNA-binding domain) is correctly folded and accessible to DNA in all cases.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept