WD mice were treated with intragastric administration with GDL, penicillamine, and GDL plus penicillamine. Ratios of Ki67+ (A,B), BrdU+ (C,D), Tuj1+ (C,E), MAP2+ (C,F), and TUNEL+ (C,G) cells were determined in the hippocampal regions in WD mice. *P<0.05, **P<0.01, compared with control; #P<0.05, ##P<0.01, compared with model.