(A) Cryo-electron microscopy structures of the pre- and post- fusion spike protein (PDB: 6VSB & 6XRA) (B), with the N-terminal domain (NTD), Receptor binding domain (RBD), C-terminal domain (CTD) 1 & 2, central helix (CH), Fusion peptide proximal region (FPPR), Heptad repeat (HR) 1 & 2 coloured pale blue, pale pink, forest green, pale green, wheat, blue, pale yellow and raspberry, respectively. (C) Expanded view of the homotrimeric arrangement of the RBD domains which can move from an open to closed conformation. The antibody derived fragment antigen-binding (FAB, shown grey) bound complexes of the S-protein RBD domains in both the open and closed conformation (PDB: 6ZDH & 6WPS) (D). (E) Complex structure of the RBD domain bound to the full-length homodimeric human ACE2 receptor including the peptidase domain (PD) and collectrin-like domain (CLD) in complex with B⁰AT1 shown wheat and pale yellow, respectively (PDB: 6M1D). (F) Structural comparison of three structures of the Nucleocapsid protein RNA binding domain (RBD) domain illustrating the movement of the β-hairpin loop (PDB: 6VYO, 6WKP & 6M3M) and the obligate dimer of the NP dimerisation domain (PDB: 6WZO), (G).