(A) MTT assay was performed to analyze the sorafenib resistance of HepG2 cells and HepG2/SOR (sorafenib-resistant) cells treated with various concentrations of sorafenib. (B) Relative levels of FAM225A in HepG2 and HepG2/SOR cells was measured by RT-qPCR analysis. **P<0.01, compared with HepG2.