Treatment with ebselen has positive effects on colonic diameter changes induced by CS
(A) Representative spatiotemporal maps of sham and 2 months CS mice treated with vehicle (5% CM-cellulose in PBS). (B) Representative spatiotemporal maps of sham and 2 months CS mice treated with ebselen (10 mg/kg). (C) Both vehicle and ebselen treatment restored CMMC frequency of CS exposed mice to sham levels (P>0.05). (D) Vehicle-treated CS mice had a reduced colonic diameter compared with sham mice (****P<0.0001) and ebselen-treated CS mice had an increased colonic diameter compared with CS+vehicle mice (****P<0.0001); horizontal scale bar = Time (1 min); vertical scale bar = 0.5 cm (length of colon). *P<0.05.