Representative images of mouse colon at 2 and 6 months CS exposure (A and F, respectively). Shortening of the colon was observed after 2 months (B) and 6 months (G) CS exposure. Number of faecal pellets increased within the dissected colon at 2 months (C) and 6 months (H) CS mice. SI length was unaffected after 2 months (D) and 6 months CS (I) increased the SI length. Caecal weights were not changed at 2 months (E) and 6 months (J) of CS exposure. CS cessation for 10 days following 2 months CS did not rescue altered colon length and faecal pellet counts (B and C); *P<0.05, **P<0.01, ****P<0.0001.