Proteins of the specified Reactome pathways forming nodes with the most edges are marked. (A) Reactome pathways in HeLa: TCA cycle and respiratory electron transport, translation, RNA metabolism. (B) Reactome pathways in MCF7: cell cycle, translation and RNA metabolism. Septin cluster, representing a distinct PFAM protein domain is marked separately, although septins are also involved in the regulation of cell cycle. Generated using STRING 11.0. Abbreviation: TCA cycle, tricarboxylic acid cycle.