(A) Shows the change in trend of IL-6 content, and (B) refers to the change in trend of TNF-α content. The contents of IL-6 and TNF-α in SKOV3/DDP cells were higher than those in SKOV3 cells. The contents of IL-6 and TNF-α in the serum of mice with a circadian-rhythm disorder were higher than those of mice with a normal circadian rhythm. The F value for IL-6 was 129.63 (**P<0.01, OC/LL or R-OC/LD vs OC/LD, R-OC/LL vs R-OC/LD; ***P<0.001, R-OC/LL vs OC/LD) and the F value for TNF-α was 197.179 (**P<0.01, OC/LL or R-OC/LD vs OC/LD, R-OC/LL vs R-OC/LD; *** P<0.001, R-OC/LL vs OC/LD. Two weeks after DDP administration, the serum levels of IL-6 and TNF-α were lower than those 1 week after DDP administration.