NM23 deficiency could significantly attenuate SiHa cells apoptosis (A), promote cells invasion (B,C) and growth (D) and, while overexpression of NM23 had the opposite effect which could be partially blocked by overexpression of LINC00636. Western blot showed that impact of NM23 and LINC00636 SiHa cells might be through regulating Bcl2 and BAX expression (E). The in vivo xenograft showed that LINC006363 knockdown significantly up-regulated NM23 expression, while LINC00636 down-regulated it (F). Graphic summary of the present study, the LINC00636 plays a negative regulatory role in cervical cancer metastasis, which could be achieved by targeting NM23 (G). Values were presented as means ± SDs of three independent experiments unless indicated. *: P<0.05, **: P<0.01, ***: P<0.001.