Figure 4
Transcription levels of BMP4 (A), RARRES2 (B), SFRP2 (C), TGFβ2 (D) and WIF1 (E) were decreased in saline-treated bleomycin mice compared with control mice. Gene transcription of TGIF1 (F) in term hAEC treatment groups was comparable with control level and was remained higher than saline and preterm hAEC-treated groups. There was no difference in MYC (G) levels between term and preterm hAECs; however, the level of MYC (H) was increased only in term hAEC treatment groups compared with other groups (*P<0.05, **P<0.01, ***P<0.001, ****P<0.0001).
Changes of Wnt/β-catenin pathway related gene transcription levels in mouse lung tissues on D14 ( n=6), and gene transcription level of MYC in term/preterm hAECs.

Transcription levels of BMP4 (A), RARRES2 (B), SFRP2 (C), TGFβ2 (D) and WIF1 (E) were decreased in saline-treated bleomycin mice compared with control mice. Gene transcription of TGIF1 (F) in term hAEC treatment groups was comparable with control level and was remained higher than saline and preterm hAEC-treated groups. There was no difference in MYC (G) levels between term and preterm hAECs; however, the level of MYC (H) was increased only in term hAEC treatment groups compared with other groups (*P<0.05, **P<0.01, ***P<0.001, ****P<0.0001).

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