(A) Quantification of the Ki-67 positive cells present in wild type and Hfe^−/−mouse crypts. Data show mean values (±SEM) for three mice per group. (B) The permeability of the wild type and Hfe^−/− mouse intestinal tracts was monitored by the accumulation of the FITC-Dextran in the serum upon its administration by oral gavage. Data are represented as mean values (±SEM) for five mice per group. (C–F) The degree of inflammation of the experimental colitis in Hfe^−/− mice (□) and wild type (▪) mice was assessed by measuring daily body index that consisted of observing body weight change, rectal bleeding, diarrhea and upon the sacrifice, colon weight. Data show mean values (±SEM) for five mice per group. *P < 0.05; **P < 0.01; ***P < 0.001.