Figure 3
(A) Representative bright-field optical microscopy (OM, bar = 50 μm) and EM images (bar = 250 nm) of the transdifferentiation of MCs in the different groups. Anti-dsDNA antibodies induced myofibroblast-like phenotype transdifferentiation of MCs (indicated by the red arrows in OM and the black arrows in EM), and emodin ameliorated the transdifferentiation. (B) Relative expression of ICAM-1 and TNF-α in the MCs of the different groups (real-time PCR). (C) Representative Western blots showing the ICAM-1 and TNF-α levels in MCs from the different groups. (D) Relative ICAM-1 levels in MCs from the different groups (Western blot). *P<0.05 compared with the control group; #P<0.05 compared with Group A. Control, normal group; Group A, anti-dsDNA group; Group B, anti-dsDNA + emodin group.
The levels of TNF-α and ICAM-1 and the ultrastructure of the different MC groups treated with or without emodin

(A) Representative bright-field optical microscopy (OM, bar = 50 μm) and EM images (bar = 250 nm) of the transdifferentiation of MCs in the different groups. Anti-dsDNA antibodies induced myofibroblast-like phenotype transdifferentiation of MCs (indicated by the red arrows in OM and the black arrows in EM), and emodin ameliorated the transdifferentiation. (B) Relative expression of ICAM-1 and TNF-α in the MCs of the different groups (real-time PCR). (C) Representative Western blots showing the ICAM-1 and TNF-α levels in MCs from the different groups. (D) Relative ICAM-1 levels in MCs from the different groups (Western blot). *P<0.05 compared with the control group; #P<0.05 compared with Group A. Control, normal group; Group A, anti-dsDNA group; Group B, anti-dsDNA + emodin group.

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