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Figure 2

(A) In GSE49149, a total of 367 hypermethylated genes (red dots) and 39 hypomethylated genes (green dots) were identified (|log2 FC| > 1 and P<0.05). (B) Heatmap of the 50 PMDGs. The mRNA values of PMDGs were negatively correlated with the promoter methylation levels (P<0.05), and the mRNA levels of PMDGs were associated with the OS of the PC cohort of TCGA (P<0.05). The red and blue bars on the top represent tumor and normal samples, respectively. Colors changing from mazarine (low) to crimson (high) represent the homogenized β-value of the gene promoter in GSE49149.

Identification of differentially methylated genes across the whole gene promoters

(A) In GSE49149, a total of 367 hypermethylated genes (red dots) and 39 hypomethylated genes (green dots) were identified (|log₂ FC| > 1 and P<0.05). (B) Heatmap of the 50 PMDGs. The mRNA values of PMDGs were negatively correlated with the promoter methylation levels (P<0.05), and the mRNA levels of PMDGs were associated with the OS of the PC cohort of TCGA (P<0.05). The red and blue bars on the top represent tumor and normal samples, respectively. Colors changing from mazarine (low) to crimson (high) represent the homogenized β-value of the gene promoter in GSE49149.

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