The results indicated five SFs (HSPB1, MBNLS, MSI, SNRPN, YBX3) were correlated with 177 ASEs. Of the 187 pairs of corelation cases, 104 pairs were negatively regulated (green lines) and 83 pairs were positively regulated (red lines). Of the 177 ASEs, 79 were high-risk events (red ovals) and 98 were low-risk events (green ovals) (A). Venn plot for displaying OS-SEs associated metastasis and clinical status, among the 177 ASEs, 18 ASEs were significantly connected with bone metastasis, ABCA6-43162-AT and PLIN5-46808-AT were identified to be both associated with OS (P=0.041, P=0.048), bone metastasis (P=0.032, P=0.019) and co-expressed with SFs (cor = 0.410, P=1.05E-15; cor = −0.416, P=3.83E-16) (B). Beeswarm plots demonstrating OS-SEs, ABCA6-43162-AT and PLIN5-46808-AT, were significantly associated with metastasis and clinical status (C–H).