(A) The mRNA expression level of MCM3 in CCLE database. MCM3 mRNA expression level ranks 15th among a group of human cancers (shown in red frame). (B) The mRNA expression levels of MCM family members in various types of cancer versus normal tissues in the Oncomine database. The blue box in the graph indicates that the target gene is down-regulated in the corresponding tumor, while red indicates up-regulated genes, with statistically significant differences (P = 1 × 10⁻⁴). The number in the cell represents the number of studies that meet the set threshold. The color of the cells is determined by the rank of gene expression differences; CCLE, cancer cell line encyclopedia.