(A,B) Scotopic ERG a-wave (A) and b-wave (B) were measured in WT rats and hCRP-Tg rats (Tg) with indicated duration of STZ-induced diabetes (DM). Light intensity of 600 cd.s/m² was used. (C) Representative TUNEL images in retinal sections of 6-month-old diabetic WT rats and diabetic hCRP-Tg rats. White arrows indicate TUNEL-positive cells (red). Scale bar = 25 μm. (D) Quantification of TUNEL-positive cells (n=8–12). (E) Cell death ELISA was performed in the retinas of 6-month-old diabetic WT rats and diabetic hCRP-Tg rats (n=8–12). Data were presented as mean ± SEM. *P<0.05, **P<0.01, ***P<0.001. Abbreviation: INL, inner nuclear layer.