(A) Dexamethasone (DEX) induced a fast increase of KLF15 mRNA expression. (B) After treatment of DEX, the mRNA expression of NFATc1 was reduced and was minimal at 24 h. (C)Representative Western blots and quantitative band intensity analysis for NFATc1 protein expression levels in con- or DEX–treated podocytes. NFATc1 protein expression was decreased in DEX treated podocytes. (D) Compared with DEX-treated groups, the mRNA expression of NFATc1 was up-regulated in KLF15 silenced podocytes under DEX stimulation. (E) Western blot analysis also verified that the protein expression of NFATc1 was increased in KLF15 knockdown podocytes after DEX treatment. Data were from at least three independent experiments. *P<0.05, ** P<0.01 vs. controls.