KLF15 is down-regulated in podocytes in proteinuric patients
Immunostaining for the podocyte specific maker WT1 (green) and KLF15 (red) was performed in glomeruli of proteinuric patients and normal samples from patients with renal cell carcinoma. Representative confocal images showed that KLF15 was enriched in normal glomeruli and was obviously reduced in glomeruli of patients with diabetic nephropathy (DN, n=4), minimal change disease (MCD, n=3) or focal segmental glomerulosclerosis (FSGS, n=3). The arrows mark KLF15 expression in podocyte; scale bars: 50 μm.