(A) HE staining was used to observe the pathological condition of synovial tissue in each group (×400). (B) TUNEL staining was used to detect the apoptosis of rat synoviocytes (×200). (C) The apoptosis cells in each group. (D) Western blot assay was used to detect the expression of apoptosis-related proteins in the synovial tissue. The data analysis was performed using one-way ANOVA, followed by pairwise comparison using LSD-t. ^aP<0.05 vs. the normal group; ^bP<0.05 vs. the mimic-NC group; ^cP<0.05 vs. the sh-NC group; ^dP<0.05 vs. the miR-101-3p inhibitors + sh-NC group.