Datasets from Material 2 including LTSs with (LTS+) and without (LTS−) COPD compared with HNSs are shown as level of: (A) cotinine in serum; (B) leukocyte count in blood samples; (C) CRP in serum; (D) neutrophil elastase protein in BAL samples; (E) net gelatinase activity (relative fluorescence intensity, rFI) in BAL samples and (F) net serine proteinase activity (relative absorbance intensity, rAI) in BAL samples. Bars depict the median and interquartile range for each study group. Analytical statistics are shown according to Kruskal–Wallis one-way ANOVA on ranks (n=4–8).