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Figure 3.

(A) Summary of estimates of free energies for integral protein interactions of cholesterol (green), CDL (purple), and PIP2 (orange). The data for this graph were derived from the range of simulation studies (both coarse-grained and atomistic) discussed in the main text. Data are plotted as box and whiskers, showing the 5–95 percentile range. Data plotted in Prism 7 (GraphPad). (B) Cholesterol, CDL, and PIP2, indicating the likely charge state of the anionic lipids.

Computational estimates of protein–lipid interaction free energies.

(A) Summary of estimates of free energies for integral protein interactions of cholesterol (green), CDL (purple), and PIP₂ (orange). The data for this graph were derived from the range of simulation studies (both coarse-grained and atomistic) discussed in the main text. Data are plotted as box and whiskers, showing the 5–95 percentile range. Data plotted in Prism 7 (GraphPad). (B) Cholesterol, CDL, and PIP₂, indicating the likely charge state of the anionic lipids.

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