Coptisine relaxed ACh-induced contraction after excluding VDLCCs with nifedipine
(A) Nifedipine partly reduced the ACh-induced contraction. The resistant contraction was inhibited by coptisine (n=7/7 mice). (B) ACh could induce contraction on nifedipine pretreated mouse tracheal ring, and which was inhibited by coptisine (n=6/6 mice).