(A) 533 LUAD patients were divided into two groups: hypoxia score (HS)-high group (n = 247) and HS-low group (n = 286), according to their HS values. One-way ANOVA analysis was performed to evaluate the differences of HS in different smoking states or different tumor stages. (B) HS of LUAD patients who reformed smoking, no-smoking and smoking. (C) HS of different cancer stages. (D) Analysis of overall survival (OS) based on HS. HS-high group, n = 245; HS-low group, n = 244. (E) Analysis of disease-free survival (DFS) based on HS. HS-high group, n = 228; HS-low group, n = 229.