(A) β-Cell secretome and mice pancreatic islets (MPI) are approximately 50% similar to human pancreatic islets (HPI). (B) The filtered β-cell insulin granule (ISG) and the β-cell supernatant (SUP) share around 80% identity with the β-cell secretome. (C) β-Cell secretome (SUP2) shares 50% similarity with the β-cell supernatant (SUP). Both supernatants (SUP and SUP2) share 80.2 and 65.8%, respectively.