β-Elemene induced apoptosis through HULC-mediated apoptotic pathway in DLBCL cells
(A) HULC was up-regulated after transfection and down-regulated by knockdown of HULC in SU-DHL-8 cells. *P < 0.05 between β-elemene and control group. (B) Apoptosis rate was decreased in HULC overexpression SU-DHL-8 cells treated by β-elemene (60 μg/ml) and no significant change was found in HULC knockdown SU-DHL-8 cells treated by β-elemene (60 μg/ml) at 48 h. *P < 0.05 between HULC and vector group. #P > 0.05 between shHULC and shNC group. (C) The expression of Bax decreased, while Bcl-2 increased in HULC overexpression SU-DHL-8 cells treated by β-elemene (60 μg/ml), and the expression of Bax increased, while Bcl-2 decreased in HULC knockdown SU-DHL-8 cells treated by β-elemene (60 μg/ml) at 48 h.