Figure 1
The differences in SPAG5 mRNA expression between normal ovarian tissues and ovarian cancer tissues in the GSE40595 (A) and GSE14407 (B) datasets (all P < 0.001). The difference in SPAG5 mRNA expression between normal ovarian cells and ovarian tumors in the GSE26712 dataset (C) (P < 0.001). The differences in SPAG5 mRNA expression between various histological types in the GSE44104 dataset (D) (P = 0.009). In the GSE12172 dataset, a significant difference in SPAG5 mRNA expression was found between different TNM stages (E) (P = 0.001). SPAG5 mRNA expression was significantly lower in ovarian tumors with LMP than that in malignant ovarian cancers (F) (P < 0.001). SPAG5 mRNA expression in various wild-type, mutant, and nonmutant ovarian cancers (G) (P < 0.001). Note: K: KRAS; B: BRAF; E: ERBB2.
The relationship between SPAG5 mRNA expression and clinical characteristics in the GEO database

The differences in SPAG5 mRNA expression between normal ovarian tissues and ovarian cancer tissues in the GSE40595 (A) and GSE14407 (B) datasets (all P < 0.001). The difference in SPAG5 mRNA expression between normal ovarian cells and ovarian tumors in the GSE26712 dataset (C) (P < 0.001). The differences in SPAG5 mRNA expression between various histological types in the GSE44104 dataset (D) (P = 0.009). In the GSE12172 dataset, a significant difference in SPAG5 mRNA expression was found between different TNM stages (E) (P = 0.001). SPAG5 mRNA expression was significantly lower in ovarian tumors with LMP than that in malignant ovarian cancers (F) (P < 0.001). SPAG5 mRNA expression in various wild-type, mutant, and nonmutant ovarian cancers (G) (P < 0.001). Note: K: KRAS; B: BRAF; E: ERBB2.

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