An overview of proposed mechanisms whereby Notch3 signalling influences PASMC function, in the context of normal and overactive Notch3 signalling
Under normal conditions, Notch3 is an important regulator of the contractile phenotype in VSMCs. Under conditions of increased Notch3/Notch3 activity, VSMCs undergo changes promoting a synthetic, proliferative and pro-survival phenotype in PASMCs.