(A) LRRK2 regulates Mycobacterium tuberculosis control and phagocytosis via PI3K complex and Rubicon inhibition. (B) LRRK2 regulates inflammation in response to Salmonella by forming a complex with and phosphorylating the NLRC4 inflammasome, modulating IL-1β production. (C) LRRK2 interacts with the NRON complex, mediating NFAT translocation and LPS-induced inflammation. (D) LRRK2 lies downstream of the Dectin-1 receptor and modulates NF-κB-signalling via TRAF6 and TANK1 interaction. (E) LRRK2 mediates NF-κB-signalling via PKA inhibition. (F) LRRK2 phosphorylates RCAN1 regulating NF-κB and NFAT signalling (G) LRRK2 phosphorylates key components of the MAPK pathway, MAP2K3/6 and MAP2K4/7, leading to p38 and JNK nuclear translocation and increased inflammatory responses.