(A) LRRK2 stabilizes Rab10 and Rab8 onto secretory lysosomes via phosphorylation during cellular stress. (B) LRRK2 is recruited to autophagosomes upon LPS treatment. (C) LRRK2 inhibits autophagic flux via Beclin-1 inhibition. (D) LRRK2 phosphorylates Rab10, which is found on recycling phagosomes. (E) LRRK2 modulates phagosome fusion with early endosomes via WAVE2 complex formation and Rab5a interaction. (F) LRRK2 phosphorylates Rab7 via the phosphorylation of Rab8a, mediating late phagosome and lysosome function.