(A) The qRT-PCR assay indicated the expression level of circFMN2 in CRC cell lines was generally higher than that in the HCoEpiC normal colonic cell line. (B) The qRT-PCR assay indicated the expression level of circFMN2 in HCT116 cells treated with si-circFMN2. Data are the mean ± SD of three experiments. (C) The qRT-PCR assay indicated the expression level of circFMN2 in HT-29 cells infected with circFMN2 overexpression plasmid. (D) CCK8 assay showed that circFMN2 knockdown significantly repressed cell proliferation of HCT116 cells. (E) CCK8 assay showing overexpression of circFMN2 promoted the proliferation of HT-29 cells. (F) Colony formation assay showed that the knockdown of circFMN2 significantly restrained the proliferation of HCT116 cells, while ectopic expression of circFMN2 significantly promoted the proliferation of HT-29 cells. *P<0.05, **P<0.01.