(A) The heat map showed the top ten most increased and decreased circRNAs in CRC tissues as compared with that in the matched non-tumor tissues analyzed by circRNAs Arraystar Chip. (B) The level of hsa_circ_0005100 was significantly increased in tumor tissues as compared with that in matched non-tumor tissues of 88 pairs of CRC patients. (C) The level of hsa_circ_0001821 was significantly increased in tumor tissues as compared with that in matched non-tumor tissues of 88 pairs of CRC patients. (D) The level of hsa_circ_0084188 was significantly increased in tumor tissues as compared with that in matched non-tumor tissues of 88 pairs of CRC patients. (E) The level of hsa_circ_0000372 was not significantly increased in tumor tissues as compared with that in matched non-tumor tissues of 88 pairs of CRC patients; P=0.09. (F) The level of hsa_circ_0001178 was significantly increased in tumor tissues as compared with that in matched non-tumor tissues of 88 pairs of CRC patients. ***P<0.001.