(A) Etomoxir could inhibit fatty acids transportation into mitochondrion. (B) Heat map of the top 50 DEGs in BCa compared with normal bladder tissues. Red represents up-regulation and green represents down-regulation. (C) Enrichment of functions of DEGs revealed a strong relation with fatty acid metabolism and lipid catabolic process. (D) GO-map network analysis indicated that glycerolipid metabolism and fatty acid degradation were linked with BCa through PPAR signaling pathway, and cell cycle was closely related to BCa. (E) FFA level in BCa was higher than in paired paracancerous tissues (n=9). **P<0.01. Abbreviations: DEG, differentially expressed gene; FFA, free fatty acid; GO, gene ontology.